The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

Leukemia. 2010 Jul;24(7):1249-57. doi: 10.1038/leu.2010.104. Epub 2010 Jun 3.


Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • GATA Transcription Factors / physiology*
  • Hematopoiesis / physiology*
  • Humans
  • Leukemia / metabolism*
  • Leukemia / pathology
  • Proto-Oncogene Proteins / physiology*
  • Trans-Activators / physiology*


  • GATA Transcription Factors
  • Proto-Oncogene Proteins
  • Trans-Activators
  • proto-oncogene protein Spi-1