High intensity focused ultrasound ablation of pancreatic neuroendocrine tumours: report of two cases

Cardiovasc Intervent Radiol. 2011 Apr;34(2):419-23. doi: 10.1007/s00270-010-9884-0. Epub 2010 Jun 3.


We describe the use of ultrasound-guided high-intensity focused ultrasound (HIFU) for ablation of two pancreatic neuroendocrine tumours (NETs; insulinomas) in two inoperable young female patients. Both suffered from episodes of severe nightly hypoglycemia that was not efficiently controlled by medical treatment. After HIFU ablation, local disease control and symptom relief were achieved without postinterventional complications. The patients remained free of symptoms during 9-month follow-up. The lesions appeared to be decreased in volume, and there was decreased enhancing pattern in the multidetector computed tomography control (MDCT). HIFU is likely to be a valid alternative for symptoms control in patients with pancreatic NETs. However, currently the procedure should be reserved for inoperable patients for whom symptoms cannot be controlled by medical therapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Follow-Up Studies
  • High-Intensity Focused Ultrasound Ablation / methods*
  • Humans
  • Magnetic Resonance Imaging
  • Neuroendocrine Tumors / diagnosis*
  • Neuroendocrine Tumors / therapy*
  • Pancreas / diagnostic imaging
  • Pancreas / pathology
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / therapy*
  • Tomography, X-Ray Computed
  • Ultrasonography