Restriction and complexity of Mcf2 proto-oncogene expression

Oncogene. 1991 May;6(5):833-9.


MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the gonads and tissues of neuroectodermal origin. It also identifies an exon encoding 42 amino acids that is alternatively spliced in murine, but not human testis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Cosmids
  • Exons
  • Gene Expression
  • Guanine Nucleotide Exchange Factors
  • Humans
  • Kinetics
  • Male
  • Mice
  • Molecular Sequence Data
  • Organ Specificity
  • Polymerase Chain Reaction / methods
  • Protein-Tyrosine Kinases / genetics*
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • RNA Splicing
  • RNA, Messenger / genetics
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Testis / physiology
  • X Chromosome*


  • Guanine Nucleotide Exchange Factors
  • MAS1 protein, human
  • MCF2 protein, human
  • Mcf2 protein, mouse
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Protein-Tyrosine Kinases