Feasibility of assessing [(18)F]FDG lung metabolism with late dynamic PET imaging

Mol Imaging Biol. 2011 Apr;13(2):378-84. doi: 10.1007/s11307-010-0345-6.


Purpose: The aim of this work was to non-invasively establish the feasibility of assessing 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG) lung metabolism with the use of a late dynamic positron emission tomograpy (PET) acquisition, i.e., beyond 2 h after injection.

Procedures: The present method has been probed in 11 patients without any respiratory disease, under fasting conditions, by assessing mean values of (18)F-FDG lung metabolism. A kinetic model analysis has been implemented on a simple calculation sheet. An arbitrary (population based) input function has been used in each individual, which was obtained from literature data.

Results: In the healthy lung, no (18)F-FDG release was found, and the mean values (±SD) of the (18)F-FDG uptake rate constant and of the fraction of the free tracer in blood and interstitial volume were: K = 0.0016 min(-1) (±0.0005), and F = 0.18 (±0.10), respectively. These results were in very close agreement with literature data that were obtained by both three-compartment model analysis and Patlak graphical analysis (gold standards), and that used an invasive blood sampling. Furthermore, K and the standard uptake value index have been compared.

Conclusion: We conclude that assessing lung metabolism of (18)F-FDG in humans with the use of late dynamic PET imaging is feasible. The arbitrary input function of this non-invasive feasibility study could be replaced in further experiments by an input function obtained by arterial sampling. It is suggested that this method may prove useful to quantify (18)F-FDG lung metabolism under pathological conditions.

MeSH terms

  • Aged
  • Computer Simulation
  • Feasibility Studies
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Humans
  • Kinetics
  • Lung / diagnostic imaging*
  • Lung / metabolism*
  • Middle Aged
  • Models, Biological
  • Positron-Emission Tomography / methods*
  • Tomography, X-Ray Computed


  • Fluorodeoxyglucose F18