Atherogenic dyslipidemia: cardiovascular risk and dietary intervention

Lipids. 2010 Oct;45(10):907-14. doi: 10.1007/s11745-010-3408-1. Epub 2010 Jun 4.


Atherogenic dyslipidemia comprises a triad of increased blood concentrations of small, dense low-density lipoprotein (LDL) particles, decreased high-density lipoprotein (HDL) particles, and increased triglycerides. A typical feature of obesity, the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus, atherogenic dyslipidemia has emerged as an important risk factor for myocardial infarction and cardiovascular disease. A number of genes have now been linked to this pattern of lipoprotein changes. Low-carbohydrate diets appear to have beneficial lipoprotein effects in individuals with atherogenic dyslipidemia, compared to high-carbohydrate diets, whereas the content of total fat or saturated fat in the diet appears to have little effect. Achieving a better understanding of the genetic and dietary influences underlying atherogenic dyslipidemia may provide clues to improved interventions to reduce the risk of cardiovascular disease in high-risk individuals.

Publication types

  • Review

MeSH terms

  • Atherosclerosis / diet therapy*
  • Atherosclerosis / genetics*
  • Atherosclerosis / metabolism
  • Atherosclerosis / prevention & control
  • Cardiovascular Diseases / diet therapy*
  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / prevention & control
  • Diet*
  • Dietary Fats / adverse effects
  • Dyslipidemias / diet therapy*
  • Dyslipidemias / genetics*
  • Dyslipidemias / metabolism
  • Dyslipidemias / prevention & control
  • Humans
  • Risk Factors


  • Dietary Fats