Nonhuman primate models of human immunology

Antioxid Redox Signal. 2011 Jan 15;14(2):261-73. doi: 10.1089/ars.2010.3241. Epub 2010 Aug 30.


Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dendritic Cells / immunology
  • Humans
  • Immune System / immunology
  • Killer Cells, Natural / immunology
  • Macaca mulatta / immunology*
  • Models, Animal*
  • Models, Immunological*