Common variants in FOXP1 are associated with generalized vitiligo

Nat Genet. 2010 Jul;42(7):576-8. doi: 10.1038/ng.602. Epub 2010 Jun 6.


In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)).

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Chromosomes, Human, Pair 3 / genetics
  • Family Health
  • Forkhead Transcription Factors / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Polymorphism, Single Nucleotide*
  • Repressor Proteins / genetics*
  • Vitiligo / genetics*


  • FOXP1 protein, human
  • Forkhead Transcription Factors
  • Repressor Proteins