The aim of this study was to evaluate the relationship between itch and the well-being of patients with psoriasis. In a study of 102 patients with plaque-type psoriasis, pruritus was found in 91 (89.2%) patients during exacerbation of psoriasis. No significant correlation was found between disease severity and the presence and intensity of pruritus. However, pruritus intensity correlated significantly with patients' quality of life, feelings of stigmatization, stress experienced within a period of one month before psoriasis outbreak, and depressive symptoms. In conclusion, pruritus may have a significant negative influence on the psychosocial status of patients with psoriasis. There is a need for the development of effective anti-pruritic treatments in order to improve the well-being of patients with psoriasis.