Altered cell cycle regulation helps stem-like carcinoma cells resist apoptosis

BMC Biol. 2010 May 25;8:63. doi: 10.1186/1741-7007-8-63.

Abstract

Reemergence of carcinomas following chemotherapy and/or radiotherapy is not well understood, but a recent study in BMC Cancer suggests that resistance to apoptosis resulting from altered cell cycle regulation is crucial.

MeSH terms

  • Apoptosis / physiology*
  • Carcinoma / physiopathology*
  • Cell Cycle Proteins / metabolism*
  • Gene Expression Regulation, Neoplastic / physiology*
  • Humans
  • Hyaluronan Receptors / metabolism
  • Neoplasm Recurrence, Local / physiopathology*
  • Neoplastic Stem Cells / physiology*

Substances

  • Cell Cycle Proteins
  • Hyaluronan Receptors