A controlled study of caudal epidural injections of triamcinolone plus procaine for the management of intractable sciatica

Spine (Phila Pa 1976). 1991 May;16(5):572-5. doi: 10.1097/00007632-199105000-00015.


The management of sciatica due to lumbar nerve root compromise remains controversial, probably because few well-controlled studies of conservative management have been performed. This preliminary study assesses the efficacy of epidural injections of 80 mg triamcinolone acetonide plus 0.5% procaine hydrochloride in saline, administered via the caudal route, in a double-blind, placebo controlled trial with 1 year follow-up. Twenty-three patients were entered into the study: 12 received treatment and 11 placebo. The active group showed significant pain relief (P = 0.02) and a significant increase in mobility (P = 0.01) at 4 weeks, which resulted in improved quality of life (P = 0.02). At 1 year, subjective and objective measures improved in both groups. The improvement was greater in the actively treated group, but only the objective assessment (straight leg raise) was statistically significant.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Epidural
  • Male
  • Procaine / administration & dosage
  • Procaine / therapeutic use*
  • Sciatica / drug therapy*
  • Time Factors
  • Triamcinolone / administration & dosage
  • Triamcinolone / therapeutic use*


  • Drug Combinations
  • Triamcinolone
  • Procaine