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Controlled Clinical Trial
. 2009;49(4):230-5.
doi: 10.1159/000301075. Epub 2010 May 19.

Relationship Between Carnitine, Fatty Acids and Insulin Resistance

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Controlled Clinical Trial

Relationship Between Carnitine, Fatty Acids and Insulin Resistance

Alfred Lohninger et al. Gynakol Geburtshilfliche Rundsch. .

Abstract

Increased plasma free fatty acid (FFA) levels are a feature of insulin resistance and type 2 diabetes. The aim of the present study was to assess the effect of L-carnitine supplementation on plasma lipids and the expression of enzymes in peripheral mononucleated cells (PMNC) involved in the regulation of fatty acid and glucose oxidation. L-Carnitine supplementation of 2 g/day resulted in a significant decrease in plasma FFA and in a less pronounced diminution of the plasma triacylglycerols. In addition, a concomitant increase in the relative mRNA abundances of carnitine acyltransferases (5- to 10-fold) and of the carnitine carrier OCTN2 (12-fold) in PMNC of pregnant women was found. The results of the present study provide evidence that L-carnitine supplementation in pregnancy (2 g/day) avoids a striking increase in plasma FFA, which are thought to be the main cause of insulin resistance and consequently gestational diabetes mellitus.

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