Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model

PLoS One. 2010 Jun 3;5(6):e10943. doi: 10.1371/journal.pone.0010943.


beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in younger individuals. We used a gamma-secretase inhibitor to lower beta-amyloid levels in young mice that model DS. This treatment corrected learning deficits characteristic of these mice, suggesting that beta-amyloid-lowering therapies might improve cognitive function in young DS patients.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Disease Models, Animal*
  • Down Syndrome / metabolism*
  • Enzyme Inhibitors / pharmacology
  • Learning*
  • Memory*
  • Mice
  • Mice, Transgenic


  • Amyloid beta-Peptides
  • Enzyme Inhibitors
  • Amyloid Precursor Protein Secretases