Management of cryptococcal meningitis in sub-saharan Africa

Curr HIV/AIDS Rep. 2010 Aug;7(3):134-42. doi: 10.1007/s11904-010-0052-6.


Cryptococcal meningitis (CM) is a common form of meningitis in sub-Saharan Africa due to the high prevalence of HIV/AIDS. This report outlines the management of CM with a focus on resource-limited settings. Sections covered include epidemiology and diagnosis, pharmacotherapy, management of complications, timing of antiretrovirals, and primary and secondary prevention of CM. Emphasis has been given to recent articles and landmark trials, and opinion is given from the authors' own experiences.

Publication types

  • Review

MeSH terms

  • Africa South of the Sahara / epidemiology
  • Anti-HIV Agents / therapeutic use
  • Antifungal Agents / therapeutic use
  • Cryptococcus neoformans / drug effects
  • Developing Countries*
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Infections / epidemiology
  • HIV Infections / prevention & control
  • Health Resources
  • Humans
  • Immune Reconstitution Inflammatory Syndrome / drug therapy
  • Meningitis, Cryptococcal / complications
  • Meningitis, Cryptococcal / diagnosis
  • Meningitis, Cryptococcal / drug therapy*
  • Meningitis, Cryptococcal / epidemiology
  • Prevalence
  • Randomized Controlled Trials as Topic


  • Anti-HIV Agents
  • Antifungal Agents