HAT trick: p300, small molecule, inhibitor

Chem Biol. 2010 May 28;17(5):417-8. doi: 10.1016/j.chembiol.2010.05.002.


p300 is an acetyltransferase that targets histone and nonhistone proteins for lysine acetylation. Based on a p300 structure, Bowers et al. (2010) have conducted an in silico screen for active site small molecule inhibitors of p300. We describe this important discovery and its potential therapeutic applications.

Publication types

  • Comment