The risk of relapse after a clinically isolated syndrome is related to the pattern of oligoclonal bands

J Neuroimmunol. 2010 Sep 14;226(1-2):143-6. doi: 10.1016/j.jneuroim.2010.05.032. Epub 2010 Jun 9.


We prospectively assessed the risk of second relapse in 192 patients with clinically isolated syndromes (CIS) divided into three groups: patients lacking oligoclonal IgG bands (OC-IgG, 25.7%), those showing OC-IgG (52.4%), and those with both OC-IgG and lipid-specific IgM bands (LS-OC-IgM, 22%). OC-IgG increased 9.3-fold the risk compared to lacking OC-IgG; OC-IgG+LS-OC-IgM increased the risk 39.6-fold compared to not having OC-IgG and 4.4-fold compared to having only OC-IgG. Median time to second relapse was 0.7 years for patients with OC-IgG+LS-OC-IgM and 3.3 years for those with only OC-IgG. Therefore, CSF analysis identifies CIS patients at risk of second relapse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Demyelinating Diseases / immunology*
  • Demyelinating Diseases / metabolism*
  • Demyelinating Diseases / mortality
  • Demyelinating Diseases / pathology
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / cerebrospinal fluid
  • Immunoglobulin M / blood
  • Immunoglobulin M / cerebrospinal fluid
  • Kaplan-Meier Estimate
  • Longitudinal Studies
  • Magnetic Resonance Imaging / methods
  • Male
  • Oligoclonal Bands / blood*
  • Oligoclonal Bands / cerebrospinal fluid*
  • Recurrence
  • Risk Factors
  • Young Adult


  • Immunoglobulin G
  • Immunoglobulin M
  • Oligoclonal Bands