[Fibrocystic breast disease--breast cancer sequence]

Chirurgia (Bucur). 2010 Mar-Apr;105(2):191-4.
[Article in Romanian]


Fibrocystic breast disease has developed a major issue: the breast cancer sequence. Its involvement regarding the increse of breast cancer risk has 2 aspects: it may be either the marker of a prone tissue or a premalignant hystological deffect. Difficult differential diagnosis of benign proliferative breast lession and carcinoma led to the idea of sequency between the two: cancer does not initiate on normal mammary epithelia; it takes several proliferative stages for it to occur. In our series we analized a number of 677 breast surgical procedures where the pathologic examination reveals 115 cases (17%) of coexistence between cancer and fibrocystic breast disease. This aspect has proved to be related to earlier debut of breast cancer, suggesting that epithelial hyperplasia is a risk factor for breast cancer.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Breast Neoplasms / complications*
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / etiology
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery
  • Carcinoma / complications*
  • Carcinoma / epidemiology
  • Carcinoma / etiology
  • Carcinoma / pathology
  • Carcinoma / surgery
  • Diagnosis, Differential
  • Female
  • Fibrocystic Breast Disease / complications*
  • Fibrocystic Breast Disease / epidemiology
  • Fibrocystic Breast Disease / pathology
  • Fibrocystic Breast Disease / surgery
  • Humans
  • Incidence
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Romania / epidemiology