Lymphokine-activated killer cells, natural killer cells and cytokines

Curr Opin Immunol. 1991 Feb;3(1):49-55. doi: 10.1016/0952-7915(91)90076-d.


In the past year, natural killer cells have been the subject of much active investigation. The analysis of the effect of cytokines on the generation, proliferation and function of natural killer cells, and the definition of the lymphokines that they produce, have been particularly important areas of research in view of their possible application in adaptive immunotherapy, combined with biological response modifiers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cytokines / physiology*
  • Cytotoxicity, Immunologic
  • Humans
  • Immunity, Innate*
  • Interferon Type I / physiology
  • Interleukin-2 / physiology
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / metabolism
  • Mice


  • Cytokines
  • Interferon Type I
  • Interleukin-2