A case of chronic hepatitis C developing insulin-dependent diabetes, thyroid autoimmunity and stiff-person syndrome as complications of interferon therapy

G Scavone; F Zaccardi; A Manto; S Caputo; D Pitocco; G Ghirlanda

doi:10.1016/j.diabres.2010.05.006

A case of chronic hepatitis C developing insulin-dependent diabetes, thyroid autoimmunity and stiff-person syndrome as complications of interferon therapy

Diabetes Res Clin Pract. 2010 Aug;89(2):e36-8. doi: 10.1016/j.diabres.2010.05.006. Epub 2010 Jun 11.

Authors

G Scavone¹, F Zaccardi, A Manto, S Caputo, D Pitocco, G Ghirlanda

Affiliation

¹ Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy. jekoide80@yahoo.it

PMID: 20541278
DOI: 10.1016/j.diabres.2010.05.006

Abstract

We describe the case of a 66-year-old man with chronic hepatitis C who developed type 1 diabetes mellitus (T1DM) and thyroid autoimmunity during Interferon alpha (INFalpha) therapy and then stiff-person syndrome (SPS). This is the first reported case in which SPS has appeared as complication of IFNalpha therapy.

Publication types

Case Reports

MeSH terms

Aged
Autoimmunity / drug effects*
Diabetes Mellitus, Type 1 / chemically induced*
Hepatitis C, Chronic / drug therapy*
Humans
Interferon-alpha / adverse effects*
Interferon-alpha / therapeutic use*
Male
Stiff-Person Syndrome / chemically induced*
Thyroid Gland / immunology*
Thyroid Gland / pathology

Substances

Interferon-alpha