Topoisomerase IB-DNA interactions: X marks the spot

Structure. 2010 Jun 9;18(6):661-3. doi: 10.1016/j.str.2010.05.002.


The observation made twenty years ago that type IB topoisomerases bound DNA helix-helix juxtapositions was unexpected, given the controlled helical rotation mechanism of the enzyme. In this issue, Patel et al. (2010) provide an elegant structural explanation for this interaction.

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