Mechanism of Aminoglycoside Resistance in Danish Staphylococcus Aureus Strains During the Years 1979-1987

APMIS. 1991 Jun;99(6):537-40.


A total of 49 gentamicin-resistant strains of Staphylococcus aureus isolated from blood (n = 26) or from other sites (n = 23) during the years 1979 to 1987 were evaluated for the presence of aminoglycoside-inactivating enzymes on the basis of minimum inhibitory concentrations measured by agar dilution as well as inhibition zone diameters determined by disc diffusion. Enzymatic activity was caused by AAC (6')III/APH (2") in 45 strains, and by AAC (6')III/APH (2") + APH (3') in four strains. No changes in the distribution of enzymatic activity were observed during the eight years.

MeSH terms

  • Aminoglycosides
  • Anti-Bacterial Agents / pharmacology*
  • Denmark
  • Drug Resistance, Microbial
  • Staphylococcus aureus / drug effects*
  • Time Factors


  • Aminoglycosides
  • Anti-Bacterial Agents