Aspidospermatan-aspidospermatan and eburnane-sarpagine bisindole alkaloids from Leuconotis

Chew-Yan Gan; Yun-Yee Low; Ward T Robinson; Kanki Komiyama; Toh-Seok Kam

doi:10.1016/j.phytochem.2010.05.015

Aspidospermatan-aspidospermatan and eburnane-sarpagine bisindole alkaloids from Leuconotis

Phytochemistry. 2010 Aug;71(11-12):1365-70. doi: 10.1016/j.phytochem.2010.05.015. Epub 2010 Jun 11.

Authors

Chew-Yan Gan¹, Yun-Yee Low, Ward T Robinson, Kanki Komiyama, Toh-Seok Kam

Affiliation

¹ Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

PMID: 20542302
DOI: 10.1016/j.phytochem.2010.05.015

Abstract

Leucofoline and leuconoline, representing the first members of the aspidospermatan-aspidospermatan and eburnane-sarpagine subclasses of the bisindole alkaloids, respectively, were isolated from the Malayan Leuconotis griffithii. The structures of these bisindole alkaloids were established using NMR and MS analysis, and in the case of leuconoline, confirmed by X-ray diffraction analysis. Both alkaloids showed weak cytotoxicity towards human KB cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Apocynaceae / chemistry*
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology
KB Cells
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal / chemistry*
Stereoisomerism

Substances

Antineoplastic Agents, Phytogenic
Indole Alkaloids
sarpagine