Neural dynamics of in vitro cortical networks reflects experienced temporal patterns

Nat Neurosci. 2010 Aug;13(8):917-9. doi: 10.1038/nn.2579. Epub 2010 Jun 13.

Abstract

Learning ultimately relies on changes in the flow of activity in neural microcircuits. The plasticity of neural dynamics is particularly relevant for the processing of temporal information. Chronic stimulation of cultured rat cortical networks revealed experience-dependent plasticity in neural dynamics. We observed changes in the temporal structure of activity that reflected the intervals used during training, suggesting that cortical circuits are inherently capable of temporal processing on short timescales.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cerebral Cortex / physiology
  • Learning / physiology*
  • Neural Pathways / physiology*
  • Neuronal Plasticity / physiology*
  • Organ Culture Techniques
  • Patch-Clamp Techniques
  • Rats
  • Time Factors