Abstract
We report a patient with intravascular large B-cell lymphoma who initially presented with acute ascending weakness and sensory changes. Electrodiagnostic testing and cerebral spinal fluid (CSF) studies were initially suggestive of a demyelinating polyneuropathy. Further clinical evaluation and testing were consistent with mononeuropathy multiplex. Autopsy revealed disseminated intravascular large-cell lymphoma. Intravascular large-cell lymphoma should be considered in the differential diagnosis of a rapidly evolving neuropathy associated with other organ involvement.
MeSH terms
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Anti-Inflammatory Agents / therapeutic use
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Autopsy
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Axons / pathology
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Diagnosis, Differential
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Electrodiagnosis
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Fatal Outcome
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Guillain-Barre Syndrome / cerebrospinal fluid
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Guillain-Barre Syndrome / diagnosis
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Guillain-Barre Syndrome / pathology*
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Humans
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Lymphoma, Large-Cell, Immunoblastic / cerebrospinal fluid
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Lymphoma, Large-Cell, Immunoblastic / chemically induced
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Lymphoma, Large-Cell, Immunoblastic / pathology*
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Male
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Middle Aged
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Muscle Strength / physiology
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Muscle Weakness / etiology
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Muscle, Skeletal / pathology
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Neural Conduction / physiology
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Peripheral Nerves / physiopathology
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Peripheral Nervous System Diseases / etiology
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Peripheral Nervous System Diseases / pathology
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Pupil / physiology
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Respiratory Insufficiency / etiology
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Steroids / therapeutic use
Substances
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Anti-Inflammatory Agents
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Steroids