Synthesis of chiral cyclobutane containing C3-symmetric peptide dendrimers

Org Lett. 2010 Jul 16;12(14):3148-51. doi: 10.1021/ol1010664.

Abstract

Five new highly functionalized cyclobutane containing C(3)-symmetric peptide dendrimers have been synthesized through a convergent approach from 1,3,5-trisubstituted benzene and chiral gamma,epsilon-amino diacid derivatives as well as a gamma-tetrapeptide. The first example of the synthesis of N-centered amides by using 1,3,5-triaminobenzene and a carboxylic acid is reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzene / chemistry*
  • Dendrimers / chemical synthesis*
  • Dendrimers / chemistry*
  • Peptides / chemical synthesis*
  • Peptides / chemistry*
  • Stereoisomerism

Substances

  • Dendrimers
  • Peptides
  • Benzene