The 3-7 fragment of angiotensin II is probably responsible for its psychoactive properties

Brain Res. 1991 Feb 22;542(1):49-54. doi: 10.1016/0006-8993(91)90996-9.


The abilities of angiotensin II-(3-7)-pentapeptide (A-II-(3-7), 1 nmol) and angiotensin II (A-II, 1 nmol) to influence rat's psychomotor and cognitive behaviours were compared. Both peptides, given intracerebroventricularly (i.c.v.), 15 min before the experiment, increased number of crossings, rearings and bar approaches in the open field. A-II-(3-7) as well as A-II, at the same doses and routes, significantly intensified stereotypy produced by apomorphine (1 mg/kg) and amphetamine (6.5 mg/kg), both given intraperitoneally. The 3-7 fragment of A-II and A-II in equimolar doses (1 nmol, i.c.v.) were similarly effective in improving learning of conditioned avoidance responses and recall of a passive avoidance behaviour. Taken together, these data and our previous findings indicate that, in rats, the 3-7 fragment of A-II is responsible for the psychoactive properties of angiotensins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Angiotensin II / pharmacology*
  • Animals
  • Apomorphine / pharmacology
  • Avoidance Learning / drug effects
  • Cognition / drug effects
  • Conditioning, Psychological
  • Male
  • Memory / drug effects
  • Peptide Fragments / pharmacology*
  • Psychomotor Performance / drug effects
  • Psychotropic Drugs / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Stereotyped Behavior / drug effects


  • Peptide Fragments
  • Psychotropic Drugs
  • Angiotensin II
  • angiotensin II (3-7)
  • Apomorphine