HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes

J Neuroimmunol. 2010 Sep 14;226(1-2):147-9. doi: 10.1016/j.jneuroim.2010.05.035. Epub 2010 Jun 12.


Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS).

Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells.

Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC).

Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC.

Conclusions: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies / metabolism
  • CD4 Antigens / metabolism
  • Confidence Intervals
  • ELAV Proteins / immunology*
  • Female
  • HLA-DQ Antigens / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Paraneoplastic Syndromes, Nervous System / immunology*
  • Paraneoplastic Syndromes, Nervous System / pathology
  • Small Cell Lung Carcinoma / immunology
  • Small Cell Lung Carcinoma / metabolism
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Young Adult


  • Antibodies
  • CD4 Antigens
  • ELAV Proteins
  • HLA-DQ Antigens
  • HLA-DQ2 antigen