Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment

Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(6):563-77. doi: 10.2183/pjab.86.563.


Pancreatic beta-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the beta-cells and/or a decrease in the beta-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. Clarification of the mechanisms of insulin secretion and beta-cell fate provides a basis for the understanding of diabetes and its better treatment. In this review, we discuss cell signaling critical for the insulin secretory function based on our recent studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cyclic AMP / metabolism
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / pathology*
  • Diabetes Mellitus / therapy*
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Insulin-Secreting Cells / metabolism
  • Insulin-Secreting Cells / pathology*
  • Pancreas, Exocrine / pathology
  • Signal Transduction*


  • Insulin
  • Cyclic AMP