Atypical Alzheimer's disease: a case report

Neurol Sci. 2010 Oct;31(5):643-6. doi: 10.1007/s10072-010-0334-1. Epub 2010 Jun 15.


This paper deals with an unusual case of Alzheimer's disease with early onset, no family history, myoclonus, tonic generalized seizures and pseudo-periodic spikes on EEG. The demise occurred after 8 years of progressive cognitive deterioration; the pathological examination showed "Pick-like" atrophy, neurofibrillary tangles, senile plaques, congophilic angiopathy and cerebellar amyloid plaques. The genetical research could not support the hypothesis of a mutation of Presenilin 1 and 2 genes. Anyway, the peculiarity of the phenotype is worthy to be described even in the absence of specific molecular findings.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alzheimer Disease* / diagnosis
  • Alzheimer Disease* / pathology
  • Alzheimer Disease* / physiopathology
  • Brain / pathology
  • Electroencephalography
  • Female
  • Humans
  • Neurofibrillary Tangles / pathology
  • Plaque, Amyloid / etiology
  • Tomography Scanners, X-Ray Computed