Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica

J Med Food. 2010 Aug;13(4):1019-23. doi: 10.1089/jmf.2009.1207.

Abstract

The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly exhibits antioxidant, anticancer, and anti-inflammatory effects. A search for biologically active compounds in U. davidiana var. japonica extracts yielded bakuchiol, which we structurally identified on the basis of spectral data, including two-dimensional nuclear magnetic resonance spectroscopy and distortionless enhancement by polarization transfer. In our study, bakuchiol (50 microM) inhibited lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production in RAW 264.7 macrophages by 53.7% and 84.2%, respectively. These results suggested that bakuchiol is one of the potent anti-inflammatory components of U. davidiana var. japonica.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / analysis
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology
  • Cell Line, Tumor
  • Dinoprostone / immunology
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Mice
  • Nitric Oxide / immunology
  • Phenols / analysis
  • Phenols / isolation & purification*
  • Phenols / pharmacology
  • Plant Bark / chemistry
  • Plant Extracts / analysis
  • Plant Extracts / isolation & purification*
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Plant Stems / chemistry
  • Ulmus / chemistry*

Substances

  • Anti-Inflammatory Agents
  • Phenols
  • Plant Extracts
  • Nitric Oxide
  • Dinoprostone
  • bakuchiol