Anti-osteoporotic constituents from Indian medicinal plants

Phytomedicine. 2010 Nov;17(13):993-9. doi: 10.1016/j.phymed.2010.03.014. Epub 2010 May 31.


The objective of this study was to determine the in vitro osteogenic activities of selected medicinal plants used traditionally in India. The compounds isolated from three plants viz. Allophylus serratus, Cissus quadrangularis and Vitex negundo were evaluated for their in vitro osteogenic activities. Primary cultures of osteoblasts were used to determine the effects of these components on osteoblast functions. Five of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization. These findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Density / drug effects*
  • Bone Density Conservation Agents / pharmacology*
  • Cell Differentiation / drug effects*
  • Cells, Cultured
  • Cissus
  • India
  • Osteoblasts / drug effects*
  • Osteoblasts / physiology
  • Phytotherapy
  • Plant Extracts / pharmacology*
  • Plants, Medicinal*
  • Rats
  • Rats, Sprague-Dawley
  • Sapindaceae
  • Vitex


  • Bone Density Conservation Agents
  • Plant Extracts