Acupuncture improves exercise tolerance of patients with heart failure: a placebo-controlled pilot study

Heart. 2010 Sep;96(17):1396-400. doi: 10.1136/hrt.2009.187930. Epub 2010 Jun 15.


Background: Congestive heart failure (CHF) is a complex clinical syndrome with autonomic dysbalance and increased plasma levels of inflammatory cytokines, which further worsen the syndrome. Experimental data have shown that stimulation of certain acupoints decreases autonomic dysbalance.

Objective: To test the therapeutic potential of acupuncture for life-threatening diseases such as CHF.

Methods: 17 stable patients with CHF (New York Heart Association class II-III, ejection fraction <40%) receiving optimised heart failure medication were randomised into a verum acupuncture (VA) and placebo acupuncture (PA) group. Cardiopulmonary function, heart rate variability and quality of life were explored.

Results: No improvements of the cardiac ejection fraction or peak oxygen uptake were observed, but the ambulated 6 min walk distance was remarkably increased in the VA group (+32+/-7 m) but not the PA group (-1+/-11 m; p<0.01). Accordingly, post-exercise recovery after maximal exercise and the VE/VCO(2) slope, a marker of ventilatory efficiency, were improved after VA but not PA. Furthermore, heart rate variability increased after VA, but decreased after PA. The 'general health' score and 'body pain' score of the quality-of-life questionnaire SF-36 tended to be improved after VA.

Conclusion: Acupuncture may become an additional therapeutic strategy to improve the exercise tolerance of patients with CHF, potentially by improving skeletal muscle function.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acupuncture Therapy / methods*
  • Aged
  • Autonomic Nervous System / physiopathology
  • Cytokines / blood
  • Exercise Test / methods
  • Exercise Tolerance / physiology*
  • Female
  • Heart Failure / physiopathology
  • Heart Failure / therapy*
  • Heart Rate / physiology
  • Humans
  • Inflammation Mediators / blood
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality of Life
  • Single-Blind Method
  • Treatment Outcome


  • Cytokines
  • Inflammation Mediators