Abstract
We report the first instance of macrolide resistance developing in vivo following appropriate antibiotic use in a healthy volunteer as a part of a controlled human infection with Campylobacter jejuni. In vivo development of macrolide resistance may be an important contributor to antibiotic resistance in C. jejuni.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Typing Techniques
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Campylobacter Infections / drug therapy*
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Campylobacter Infections / microbiology
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Campylobacter jejuni / classification
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Campylobacter jejuni / drug effects*
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Campylobacter jejuni / genetics
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Campylobacter jejuni / isolation & purification
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DNA Fingerprinting
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial*
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Electrophoresis, Gel, Pulsed-Field
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Healthy Volunteers
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Humans
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Macrolides / pharmacology*
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Macrolides / therapeutic use*
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Male
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Microbial Sensitivity Tests
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Young Adult
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Macrolides