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. 2010 Jun 16;30(24):8197-202.
doi: 10.1523/JNEUROSCI.0359-10.2010.

A Multimodal Assessment of the Genetic Control Over Working Memory

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Free PMC article

A Multimodal Assessment of the Genetic Control Over Working Memory

Katherine H Karlsgodt et al. J Neurosci. .
Free PMC article

Abstract

Working memory performance is significantly influenced by genetic factors. Here, we assessed genetic contributions to both working memory performance and neuroimaging measures focused on the network of brain regions associated with working memory by using a sample of 467 human participants from extended families. Imaging measures included diffusion tensor imaging indices in major white matter tracts thought to be associated with working memory and structural magnetic resonance imaging measures of frontal and parietal gray matter density. Analyses directly addressed whether working memory performance and neural structural integrity are influenced by common genetic factors (e.g., pleiotropy). While all cognitive measures, gray matter regions, and white matter tracts assessed were heritable, only performance on a spatial delayed response task and integrity of the superior longitudinal fasciculus (a primary fronto-parietal connection) shared genetic factors. As working memory may be a core component of other higher level processes, such as general intelligence, this finding has implications for the heritability of complex cognitive functions, as well as for our understanding of the transmission of cognitive deficits in mental and neurological disorders.

Figures

Figure 1.
Figure 1.
Regions of interest for gray matter density analyses: dorsolateral prefrontal and parietal lobes. Regions of activation are those identified through a meta-analysis of working memory functional MRI studies (Owen et al., 2005). The frontal and parietal regions assessed are indicated with circles.
Figure 2.
Figure 2.
Fractional anisotropy measurements were calculated for the anterior limb of the internal capsule (red), the cingulate bundle (blue), the external capsule (green), the superior fronto-occipital fasciculus (purple), and the superior longitudinal fasciculus (yellow) using the population-based, three-dimensional, DTI, cerebral white matter tract atlas developed at Johns Hopkins University, Baltimore, MD (Wakana et al., 2004).

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