60 mature white male rats were used to study the effect of infrasound at a frequency of 8 and 16 Hz, sound pressure from 110 dB to 140 dB, on hepatocytes. The duration of exposure to the given factor was 5, 10, 15, 25 and 40 days, 3 hours daily. It was found out, that diffuse changes appearing in the liver parenchyma were of the mosaic character, and were observed both in individual hepatocytes and in a whole group of cells. The degree of manifestation of changes was to a larger degree associated with the duration of exposure to infrasound and the level of sound pressure, than with the frequency.