Citric-acid-derived photo-cross-linked biodegradable elastomers

J Biomater Sci Polym Ed. 2010;21(13):1761-82. doi: 10.1163/092050609X12567178204169. Epub 2010 Jun 16.


Citric-acid-derived thermally cross-linked biodegradable elastomers (CABEs) have recently received significant attention in various biomedical applications, including tissue-engineering orthopedic devices, bioimaging and implant coatings. However, citric-acid-derived photo-cross-linked biodegradable elastomers are rarely reported. Herein, we report a novel photo-cross-linked biodegradable elastomer, referred to as poly(octamethylene maleate citrate) (POMC), which preserves pendant hydroxyl and carboxylic functionalities after cross-linking for the potential conjugation of biologically active molecules. Pre-POMC is a low-molecular-mass pre-polymer with an average molecular mass between 701 and 1291 Da. POMC networks are soft and elastic with an initial modulus of 0.07 to 1.3 MPa and an elongation-at-break between 38 and 382%. FT-IR-ATR results confirmed the successful surface immobilization of type-I collagen onto POMC films, which enhanced in vitro cellular attachment and proliferation. Photo-polymerized POMC films implanted subcutaneously into Sprague-Dawley rats demonstrated minimal in vivo inflammatory responses. The development of POMC enriches the family of citric-acid-derived biodegradable elastomers and expands the available biodegradable polymers for versatile needs in biomedical applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bandages
  • Cell Adhesion / drug effects
  • Citric Acid / chemistry*
  • Collagen / chemistry
  • Elastomers / chemistry*
  • Elastomers / metabolism*
  • Elastomers / pharmacology
  • Elastomers / toxicity
  • Female
  • Foreign-Body Reaction / chemically induced
  • Humans
  • Immobilized Proteins / chemistry
  • Maleates / chemistry
  • Materials Testing
  • Mechanical Phenomena
  • Mice
  • Molecular Weight
  • Myocytes, Smooth Muscle / cytology
  • Myocytes, Smooth Muscle / drug effects
  • NIH 3T3 Cells
  • Photochemical Processes*
  • Rats
  • Sulfhydryl Compounds / chemistry
  • Temperature
  • Tissue Engineering


  • Elastomers
  • Immobilized Proteins
  • Maleates
  • Sulfhydryl Compounds
  • poly(octamethylene maleate citrate)
  • Citric Acid
  • Collagen
  • maleic acid
  • 1,8-octanedithiol