Angiomyeloproliferative lesions following autologous stem cell therapy

J Am Soc Nephrol. 2010 Jul;21(7):1218-22. doi: 10.1681/ASN.2009111156. Epub 2010 Jun 17.


Some reports suggest that autologous hematopoietic stem cell transplantation holds potential for treatment of renal diseases such as lupus nephritis, but the safety of delivering various stem cell types (hematopoietic, mesenchymal, and endothelial precursors) is not well established. Here, we report a case of lupus nephritis treated by direct renal injection of autologous stem cells recovered from peripheral blood. The patient developed masses at the sites of injection and hematuria. We suspected transitional cell carcinoma but nephrectomy revealed that the masses were angiomyeloproliferative lesions. We believe that this previously undescribed pathologic entity is stem cell-derived or -induced. The biologic potential, including the neoplastic potential, of this lesion is unknown. This case illustrates that the development of angiomyeloproliferative lesions is a possible complication of stem cell therapy.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Transitional Cell / diagnosis
  • Diagnosis, Differential
  • Female
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Kidney / pathology
  • Kidney / surgery
  • Kidney Neoplasms / diagnosis
  • Lupus Nephritis / surgery*
  • Middle Aged
  • Myeloproliferative Disorders / diagnosis*
  • Myeloproliferative Disorders / etiology
  • Nephrectomy