Surgical lung biopsies in 418 patients with suspected interstitial lung disease in China

Intern Med. 2010;49(12):1097-102. doi: 10.2169/internalmedicine.49.3225. Epub 2010 Jun 15.


Background: The present study was aimed to evaluate the role and safety of surgical lung biopsies (SLB) in patients with interstitial lung disease (ILD) in China.

Methods: A retrospective analysis of 418 patients with ILD undergoing SLB from Chinese literature and the data of our hospital during the past ten years was performed.

Results: A total of 418 cases underwent SLB, including open lung biopsy (OLB) in 229 cases and video-assisted thoracoscopic lung biopsy (VATLB) in 189 cases. SLB yielded a specific diagnosis for 88.0% cases, and unclassifiable idiopathic interstitial pneumonia diagnosis was seen in 9.1% cases. The total postoperative complication rate was 12.0% and mortality rate was 1.9%. The diagnostic yield, post-operative complication rate, and mortality rate between VATLB and OLB had no significant difference.

Conclusion: SLB is a very useful and relatively safe procedure for diagnosis of ILD.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biopsy / methods
  • China / epidemiology
  • Female
  • Humans
  • Lung Diseases, Interstitial / diagnosis
  • Lung Diseases, Interstitial / epidemiology
  • Lung Diseases, Interstitial / pathology*
  • Lung Diseases, Interstitial / surgery*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Thoracic Surgery, Video-Assisted / methods
  • Thoracic Surgery, Video-Assisted / statistics & numerical data*
  • Young Adult