Innate IL-17-producing Cells: The Sentinels of the Immune System

Nat Rev Immunol. 2010 Jul;10(7):479-89. doi: 10.1038/nri2800. Epub 2010 Jun 18.

Abstract

The cytokine interleukin-17 (IL-17) has received considerable attention since the discovery of a distinct CD4(+) T helper (T(H)) cell subset that produces it, known as the T(H)17 cell subset. Despite the fact that most of the recent literature describes IL-17 as a T cell-secreted cytokine, much of the IL-17 released during an inflammatory response is produced by innate immune cells. In this Review, we explore the many innate immune cell populations that are an early source of IL-17 in response to stress, injury or pathogens. These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+)T cell sees its cognate antigen and initiates the T(H)17 cell developmental programme.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • Cytokines / metabolism
  • Humans
  • Immunity, Innate*
  • Infections / immunology
  • Interleukin-17 / biosynthesis*
  • Killer Cells, Natural / immunology
  • Lymphocyte Activation
  • Mice
  • Models, Immunological
  • Neutrophils / immunology
  • Nuclear Receptor Subfamily 1, Group F, Member 3 / metabolism
  • Paneth Cells / immunology
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism
  • Receptors, Aryl Hydrocarbon / metabolism
  • Signal Transduction / immunology
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology*

Substances

  • Cytokines
  • Interleukin-17
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Aryl Hydrocarbon