Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Nature. 2010 Jun 17;465(7300):966. doi: 10.1038/nature09132.
No abstract available

MeSH terms

  • Age Factors
  • Glutarates / metabolism*
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Mutation / genetics*
  • Neoplasms / physiopathology*

Substances

  • Glutarates
  • alpha-hydroxyglutarate
  • Isocitrate Dehydrogenase
  • isocitrate dehydrogenase 2, human
  • IDH1 protein, human