Blood coagulation and fibrinolysis after experimental subarachnoid hemorrhage

Acta Neurochir (Wien). 2010 Sep;152(9):1577-81; discussion 1581. doi: 10.1007/s00701-010-0699-1. Epub 2010 Jun 18.

Abstract

Background: Aneurysmal rebleeding poses a serious risk in patients with subarachnoid hemorrhage (SAH). Studies have shown that antifibrinolytic therapy with tranexamic acid has a dramatic effect on the rate of rebleeding. Therefore, changes in the fibrinolytic system could be hypothesized.

Methods: We have used an experimental SAH rat model to demonstrate serial changes in the haemostatic system as evaluated by Thromboelastography (TEG).

Results: In the SAH group, a shorter reaction time (R-time) and higher maximum amplitude (MA) were observed. In the saline group, only a shorter R-time was observed.

Conclusions: The study has shown that a hypercoagulable state is present immediately after experimental SAH is induced as determined by TEG. The reduction in R-time and rise in MA observed in the SAH group indicate that blood in the subarachnoid space is necessary to accomplish a full systemic coagulation response. This abnormality in coagulation profile seems to be a response to the acute traumatic event caused by induction of SAH.

MeSH terms

  • Animals
  • Blood Coagulation / physiology*
  • Disease Models, Animal
  • Fibrinolysis / physiology*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Secondary Prevention
  • Subarachnoid Hemorrhage / blood*
  • Subarachnoid Hemorrhage / complications*
  • Thrombophilia / blood*
  • Thrombophilia / etiology*
  • Thrombophilia / prevention & control