Physical training after percutaneous coronary intervention in patients with stable angina: effects on working capacity, metabolism, and markers of inflammation

Eur J Cardiovasc Prev Rehabil. 2010 Jun;17(3):349-54. doi: 10.1097/HJR.0b013e3283336c8d.

Abstract

Objective: Physical activity is effective in primary and secondary prevention of cardiovascular disease. In this study, we tested the hypothesis that exercise training improves glucose and lipid metabolism, the inflammatory/anti-inflammatory balance, and the outcome of elective percutaneous coronary intervention (PCI) in patients with stable coronary disease.

Methods: Sixty-two patients scheduled to undergo PCI for stable angina were randomized to intensive physical activity (n=33) consisting of home-based exercise on a bicycle ergometer or maintain their usual sedentary life (n=29). The training program started 2 months before PCI and terminated 6 months afterwards. Clinical examination, blood sampling (fasting glucose, glycated hemoglobin, lipid profile, apolipoprotein B, apolipoprotein A1, C-reactive protein, serum amyloid A, interleukin-6, interleukin-8, and interleukin-10), and maximal exercise tests were performed at inclusion, 1 week before PCI, and 3 and 6 months afterwards.

Results: Fifty-six patients [28 per group, 45 men, mean age 63 (SD 7.8) years] completed the follow-up. According to self-reports, patients in the training group exercised more often and longer [4.9 (SD 1.1) vs. 0.6 (SD 1.3) days/week, 36 (SD 12) vs. 15 (SD 31) min/session, P<0.0001]. Improvement in maximal exercise capacity was significantly better in the training group [27 (SD 27) vs. 9 (SD 27) W, P=0.02]. Exercise had no significant effects on glucose and lipid metabolism, plasma cytokines, or acute-phase reactants.

Conclusion: A home-based training program significantly improved maximal exercise capacity but did not affect glucose or lipid metabolism or markers of inflammation.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angina Pectoris / immunology
  • Angina Pectoris / metabolism
  • Angina Pectoris / physiopathology
  • Angina Pectoris / therapy*
  • Angioplasty, Balloon, Coronary*
  • Apolipoprotein A-I / blood
  • Apolipoproteins B / blood
  • Biomarkers / blood
  • Blood Glucose / metabolism
  • C-Reactive Protein / metabolism
  • Coronary Disease / immunology
  • Coronary Disease / metabolism
  • Coronary Disease / physiopathology
  • Coronary Disease / therapy*
  • Energy Metabolism*
  • Exercise Therapy*
  • Exercise Tolerance*
  • Female
  • Glycated Hemoglobin A / metabolism
  • Home Care Services*
  • Humans
  • Inflammation Mediators / blood*
  • Interleukin-10 / blood
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Lipids / blood
  • Male
  • Middle Aged
  • Serum Amyloid A Protein / metabolism
  • Sweden
  • Time Factors
  • Treatment Outcome

Substances

  • APOA1 protein, human
  • Apolipoprotein A-I
  • Apolipoproteins B
  • Biomarkers
  • Blood Glucose
  • CXCL8 protein, human
  • Glycated Hemoglobin A
  • IL10 protein, human
  • IL6 protein, human
  • Inflammation Mediators
  • Interleukin-6
  • Interleukin-8
  • Lipids
  • Serum Amyloid A Protein
  • hemoglobin A1c protein, human
  • Interleukin-10
  • C-Reactive Protein