Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds

John R Goodell; Jonathan P McMullen; Nikolay Zaborenko; Jason R Maloney; Chuan-Xing Ho; Klavs F Jensen; John A Porco Jr; Aaron B Beeler

doi:10.1021/jo901073v

Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds

J Org Chem. 2009 Aug 21;74(16):6169-80. doi: 10.1021/jo901073v.

Authors

John R Goodell¹, Jonathan P McMullen, Nikolay Zaborenko, Jason R Maloney, Chuan-Xing Ho, Klavs F Jensen, John A Porco Jr, Aaron B Beeler

Affiliation

¹ Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

Abstract

An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo[3.2.1]octanoid scaffolds will be described.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Automation
Bridged Bicyclo Compounds / chemistry*
Equipment Design
Indicators and Reagents / chemistry
Kinetics
Microfluidic Analytical Techniques / instrumentation*
Solvents / chemistry
Temperature

Substances

Bridged Bicyclo Compounds
Indicators and Reagents
Solvents

Abstract

Publication types

MeSH terms

Substances

Grants and funding