Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Am J Epidemiol. 2010 Jul 1;172(1):10-20. doi: 10.1093/aje/kwq116. Epub 2010 Jun 18.

Abstract

The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of rarer cancers. Cases (total n = 5,491) included incident primary endometrial (n = 830), kidney (n = 775), ovarian (n = 516), pancreatic (n = 952), and upper gastrointestinal tract (n = 1,065) cancers and non-Hodgkin lymphoma (n = 1,353) diagnosed in the participating cohorts. At least 1 control was matched to each case on age, date of blood collection (1974-2006), sex, and race/ethnicity (n = 6,714). Covariate data were obtained from each cohort in a standardized manner. The majority of the serum or plasma samples were assayed in a central laboratory using a direct, competitive chemiluminescence immunoassay on the DiaSorin LIAISON platform (DiaSorin, Inc., Stillwater, Minnesota). Masked quality control samples included serum standards from the US National Institute of Standards and Technology. Conditional logistic regression analyses were conducted using clinically defined cutpoints, with 50-<75 nmol/L as the reference category. Meta-analyses were also conducted using inverse-variance weights in random-effects models. This consortium approach permits estimation of the association between 25(OH)D and several rarer cancers with high accuracy and precision across a wide range of 25(OH)D concentrations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Case-Control Studies
  • China / epidemiology
  • Cohort Studies
  • Endometrial Neoplasms / epidemiology
  • Endometrial Neoplasms / prevention & control
  • Esophageal Neoplasms / epidemiology
  • Esophageal Neoplasms / prevention & control
  • Female
  • Finland / epidemiology
  • Humans
  • Kidney Neoplasms / epidemiology
  • Kidney Neoplasms / prevention & control
  • Logistic Models
  • Lymphoma, Non-Hodgkin / epidemiology
  • Lymphoma, Non-Hodgkin / prevention & control
  • Male
  • Meta-Analysis as Topic
  • Neoplasms / prevention & control*
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / prevention & control
  • Pancreatic Neoplasms / epidemiology
  • Pancreatic Neoplasms / prevention & control
  • Prospective Studies
  • Research Design*
  • Risk Factors
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / prevention & control
  • United States / epidemiology
  • Vitamin D / blood*
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / prevention & control

Substances

  • Vitamin D

Grant support