Tight junctions: is there a role in dermatology?

Arch Dermatol Res. 2010 Sep;302(7):483-93. doi: 10.1007/s00403-010-1058-z. Epub 2010 Jun 19.


A variety of tight junction (TJ) proteins including claudins, occludin, tricellulin, zonula occludens-proteins and junctional adhesion molecules have been identified in complex localization patterns in mammalian epidermis. Their expression and/or localization is frequently altered in skin diseases including skin tumors. However, our understanding of the function(s) of TJ and TJ proteins in the skin is, even though rapidly increasing, still limited. This review summarizes our current knowledge of the involvement of TJ and TJ proteins in mammalian skin in functions ascribed to TJ in simple epithelia, such as barrier function, polarity, gene expression, proliferation, differentiation, and vesicle transport.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Dermatology / trends
  • Epidermis / metabolism*
  • Epidermis / pathology
  • Humans
  • Membrane Proteins / metabolism*
  • Protein Transport
  • Skin Diseases / metabolism*
  • Skin Diseases / pathology
  • Tight Junctions / metabolism*


  • Membrane Proteins