PI3Ks in lymphocyte signaling and development

Curr Top Microbiol Immunol. 2010;346:57-85. doi: 10.1007/82_2010_45.


Lymphocyte development and function are regulated by tyrosine kinase and G-protein coupled receptors. Each of these classes of receptors activates phosphoinositide 3-kinase (PI3K). In this chapter, we summarize current understanding of how PI3K contributes to key aspects of the adaptive immune system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Cell Movement
  • Chemotaxis, Leukocyte
  • Humans
  • Immunoglobulin Class Switching
  • Lymphocytes / physiology*
  • Phosphatidylinositol 3-Kinases / physiology*
  • Receptors, Antigen, B-Cell / physiology
  • Receptors, Antigen, T-Cell / physiology
  • Signal Transduction / physiology*


  • Receptors, Antigen, B-Cell
  • Receptors, Antigen, T-Cell
  • Phosphatidylinositol 3-Kinases