Sleep disturbance and impulsive-compulsive behaviours in Parkinson's disease

J Neurol Neurosurg Psychiatry. 2011 Jun;82(6):620-2. doi: 10.1136/jnnp.2009.186874. Epub 2010 Jun 20.

Abstract

Objectives: Impulsive-compulsive behaviours (ICBs) in Parkinson's disease (PD) have been anecdotally linked with impaired sleep. The authors investigate measures of sleep in PD patients with and without ICBs, and in healthy controls.

Methods: The authors compare Parkinsonian features, measures of depression, anxiety and mania, and sleep disturbance in 30 PD patients with ICBs (PD+ICB), 62 PD patients without ICBs (PD-ICB) and 48 healthy controls.

Results: PD+ICB patients had a younger age of PD onset, took more dopamine replacement therapy (DRT) and had worse sleep, and elevated anxiety, depression and mania scores. Using multiple linear regression analyses, the total anxiety and depression scores, and presence of ICBs were the only variables associated with poorer sleep in PD.

Conclusions: PD+ICB patients may show enhanced psychomotor effects of DRT that may in turn contribute to poor sleep quality. Sleep disturbance should be specifically queried in PD+ICB patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anxiety / complications
  • Compulsive Behavior / chemically induced*
  • Compulsive Behavior / complications
  • Depression / complications
  • Dopamine Agonists / adverse effects*
  • Dopamine Agonists / therapeutic use
  • Female
  • Humans
  • Impulsive Behavior / chemically induced*
  • Impulsive Behavior / complications
  • Male
  • Middle Aged
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy
  • Parkinson Disease / psychology*
  • Sleep Wake Disorders / chemically induced*
  • Sleep Wake Disorders / complications

Substances

  • Dopamine Agonists