Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver

AJR Am J Roentgenol. 2010 Jul;195(1):13-28. doi: 10.2214/AJR.10.4392.


Objective: The purpose of this article is to review the pharmacokinetic and pharmacodynamic properties of gadoxetate disodium (Gd-EOB-DTPA), to describe a workflow-optimized pulse sequence protocol, and to illustrate the imaging appearance of focal lesions in the noncirrhotic liver.

Conclusion: Gd-EOB-DTPA allows a comprehensive evaluation of the liver with the acquisition of both dynamic and hepatocyte phase images. This provides potential additional information, especially for the detection and characterization of small liver lesions. However, protocol optimization is necessary for improved image quality and workflow.

Publication types

  • Review

MeSH terms

  • Clinical Protocols / standards*
  • Contrast Media / pharmacokinetics
  • Contrast Media / pharmacology*
  • Gadolinium DTPA / pharmacokinetics
  • Gadolinium DTPA / pharmacology*
  • Humans
  • Liver Diseases / diagnosis*
  • Magnetic Resonance Imaging / methods*


  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA