Gadoxetate disodium-enhanced MRI of the liver: part 2, protocol optimization and lesion appearance in the cirrhotic liver

AJR Am J Roentgenol. 2010 Jul;195(1):29-41. doi: 10.2214/AJR.10.4538.


Objective: The purpose of this article is to review the use of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (gadoxetate disodium [Gd-EOB-DTPA]) in the cirrhotic liver and illustrate the imaging appearance of lesions commonly encountered in the cirrhotic liver.

Conclusion: Gd-EOB-DTPA shows promise as a problem-solving tool in the cirrhotic liver because it provides additional information that may be helpful in lesion detection and characterization. Further research is needed to optimize Gd-EOB-DTPA imaging protocols in cirrhosis and develop diagnostic criteria for liver lesions in the cirrhotic liver.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Clinical Protocols / standards*
  • Contrast Media / pharmacokinetics
  • Contrast Media / pharmacology*
  • Gadolinium DTPA / pharmacokinetics
  • Gadolinium DTPA / pharmacology*
  • Humans
  • Liver Cirrhosis / diagnosis*
  • Magnetic Resonance Imaging / methods*


  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA