Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs

J Ethnopharmacol. 1991 Mar;31(3):325-31. doi: 10.1016/0378-8741(91)90018-9.


Gastric administration of encapsuled garlic powder to anaesthetized dogs induced dose-dependent (2.5 to 15 mg/kg) natriuretic and diuretic responses which reached maximum 30-40 min after garlic administration and decreased to basal levels after 100-150 min. A simultaneous decrease in arterial blood pressure was observed which continued past the 250 min-mark. High garlic doses (15 and 20 mg/kg) provoked bradycardia and T-wave inversion during the first 10-15 min of the experiment with recordings returning to normal and staying normal throughout the remainder of the experiment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthesia
  • Animals
  • Antihypertensive Agents*
  • Blood Pressure / drug effects
  • Diuretics*
  • Dogs
  • Electrocardiography
  • Female
  • Garlic*
  • Heart Rate / drug effects
  • Male
  • Natriuresis / drug effects*
  • Plants, Medicinal*


  • Antihypertensive Agents
  • Diuretics