The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis

Clin Perinatol. 2010 Jun;37(2):355-74. doi: 10.1016/j.clp.2010.03.002.


Intrauterine infection is a unique pathologic process that raises the risk for early-onset neonatal sepsis (EONS). By acting synergistically with prematurity, EONS increases the risk for adverse neonatal outcomes, including intraventricular hemorrhage and cerebral palsy. Although several pathways for the pathogenesis of fetal damage have been proposed, the basic molecular mechanisms that modulate these events remain incompletely understood. Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / analysis
  • Chorioamnionitis / diagnosis*
  • Chorioamnionitis / immunology
  • Chorioamnionitis / microbiology
  • Defensins / immunology
  • Diagnosis, Differential
  • Female
  • Glycation End Products, Advanced / immunology
  • Humans
  • Immunity, Innate
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis*
  • Pregnancy Complications, Infectious / immunology
  • Pregnancy Complications, Infectious / microbiology
  • Proteomics / methods*
  • Risk Factors
  • Sepsis / diagnosis*
  • Sepsis / immunology
  • Sepsis / microbiology
  • Signal Transduction


  • Biomarkers
  • Defensins
  • Glycation End Products, Advanced